estrogenic compounds การใช้

• Peripheral precocious puberty has been linked to exposure to exogenous estrogenic compounds.
• Also, fennel is known to contain anethole, an estrogenic compound.
• CTA was the first estrogenic compound of the triphenylethylene series to be introduced.
• Raloxifene is the second of a new class of synthetic estrogenic compounds that have selective actions on different tissues.
• Further studies have shown that most active estrogenic compound in Menerba is liquiritigenin, derived from the root of " Glycyrrhizae uralensis"
• These contribute to the buildup of estrogenic compounds in the environment, which some scientists believe may explain falling sperm counts and premature maturation in girls.
• Some studies indicate that visceral adiposity, together with lipid dysregulation and maternal smoking, estrogenic compounds in the diet and endocrine-disrupting chemicals may be important also.
• However, according to other measures of pollution ( e . g ., phosphorus, estrogenic compounds, discarded pharmaceuticals ), the river waters are slightly more contaminated than before 1972.
• CTA was derived from estrobin ( DBE ), a derivative of the very weakly estrogenic compound triphenylethylene ( TPE ), which in turn was derived from structural modification of diethylstilbestrol ( DES ).
• But Dr . Benita Katzenellenbogen and her colleagues at the University of Illinois have shown that different estrogenic compounds react with the receptor lock in different ways, resulting ultimately in different effects on neighboring genes.
• Both tamoxifen and raloxifene take advantage of the discovery that molecular receptors for estrogen found throughout the body behave differently in different tissues, depending on the nature of the estrogenic compound that hooks up with them.
• It is an estrogenic compound which acts as a selective agonist of the ER? subtype of the estrogen receptor ( ER ), though it is also reported to act as an ER? partial agonist at sufficient concentrations.
• Critics note societies where estrogen-rich foods are a major part of the diet-- notably China and Japan-- show lower than usual levels of breast and prostate cancer, and that concentrations of estrogenic compounds in the environment are hundreds of times weaker than the hormones to which the body exposes itself.